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Loxapine (LOKS a peen)

Adult Medication

Brand Names: U.S.

Adasuve; Loxitane [DSC]

Brand Names: Canada

Apo-Loxapine; Dom-Loxapine; Loxapac; PHL-Loxapine; Xylac

Warning

All products:

  • There is a higher chance of death in older adults who take this drug for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This drug is not approved to treat mental problems caused by dementia.

Inhalation:

  • This drug can cause you to have very bad breathing problems or to stop breathing. This drug will be given to you in a hospital or doctor’s office. You will be closely watched. Do not use this drug if you have ever had lung or breathing problems like asthma or COPD (chronic obstructive pulmonary disease). Tell your doctor right away if you have wheezing, coughing, chest tightness, or shortness of breath.
  • You may only get this drug through a special program. Talk with your doctor.

What is this drug used for?

  • It is used to treat schizophrenia.
  • It is used to treat bipolar problems.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to loxapine or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

Capsule:

  • If you are very sleepy.
  • If you have recently drunk a lot of beer, wine, or mixed drinks or taken a big amount of drugs that may slow your actions like phenobarbital or some pain drugs like oxycodone.

Inhalation:

  • If you have trouble breathing.
  • If you are taking any drugs to treat lung or breathing problems like asthma or COPD.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • Avoid beer, wine, or mixed drinks.
  • Talk with your doctor before you use other drugs and natural products that slow your actions.
  • Have your blood work checked often. Talk with your doctor.
  • Low white blood cell counts have happened with drugs like this one. This may lead to a higher chance of getting an infection. Deadly infections have rarely happened. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat. Talk with your doctor.
  • Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
  • Have an eye exam as you have been told by your doctor.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Taking this drug in the third trimester of pregnancy may lead to muscle movements that cannot be controlled and withdrawal in the newborn. Talk with the doctor.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
  • Shakiness, trouble moving around, or stiffness.
  • Very bad dizziness or passing out.
  • A fast heartbeat.
  • Very bad headache.
  • Change in thinking clearly and with logic.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Seizures.
  • Slurred speech.
  • Not able to pass urine or change in how much urine is passed.
  • Feeling very tired or weak.
  • Any bruising or bleeding.
  • Enlarged breasts.
  • Nipple discharge.
  • Change in sex ability.
  • For women, no period.
  • Restlessness.
  • A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
  • Some people who take this drug may get a very bad muscle problem called tardive dyskinesia. The risk may be greater in older adults, mainly women. The chance that this will happen or that it will never go away is greater in people who take this drug in higher doses or for a long time. Muscle problems may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or if you have muscle problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Feeling sleepy.
  • Trouble sleeping.
  • Dry mouth.
  • Hard stools (constipation).

Inhalation:

  • Bad taste in your mouth.
  • Throat irritation.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.

All products:

  • Use as you have been told, even if you feel well.
  • To gain the most benefit, do not miss doses.

Capsule:

  • Take with or without food.
  • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

Inhalation:

  • For breathing in only.
  • You will be shown how to use this drug right before you take it.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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