Brand Names: U.S.
Astramorph; AVINza; Duramorph; Infumorph 200; Infumorph 500; Kadian; MS Contin
Brand Names: Canada
Doloral; Kadian®; M-Eslon®; M.O.S.-SR®; M.O.S.-Sulfate®; M.O.S.® 10; M.O.S.® 20; M.O.S.® 30; Morphine Extra Forte Injection; Morphine Forte Injection; Morphine HP®; Morphine LP® Epidural; Morphine SR; Morphine-EPD; MS Contin SRT; MS Contin®; MS-IR®; Novo-Morphine SR; PMS-Morphine Sulfate SR; ratio-Morphine; ratio-Morphine SR; Sandoz-Morphine SR; Statex®; Teva-Morphine SR
- This drug may be deadly if it is taken by accident. The chance of death may be higher in children. If this drug is taken by accident, get medical help right away.
- Keep all drugs out of the reach of children and pets.
- Do not take with beer, wine, mixed drinks, or products that have alcohol. Unsafe and sometimes deadly effects may happen.
- This drug may be habit-forming with long-term use.
- Misuse or abuse of this drug can lead to overdose and death.
- You will be watched closely to make sure you do not misuse, abuse, or become addicted to this drug.
- Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
- This drug may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.
- The chance of very bad and sometimes deadly breathing problems may be greater when you first start this drug or anytime your dose is raised. Talk with your doctor.
- Swallow whole. Do not chew, break, crush, or dissolve before swallowing. Do not inject this drug. Doing any of these things can cause very bad side effects like trouble breathing and death from overdose.
- Using this drug for a long time during pregnancy may cause the unborn baby to become addicted. This can lead to withdrawal in the newborn baby. This can be life-threatening. Talk with your doctor.
- You may sprinkle contents of capsule on applesauce. Do not chew. Swallow right away and follow with water or juice.
Long-acting and liquid products:
- Make sure you have the right drug; there is more than one strength.
- Certain strengths of this drug may only be used by people who have been taking drugs like this drug and are used to their effects. The use of these strengths by people who have not been taking drugs like this drug may cause very bad and sometimes deadly breathing problems. Talk with your doctor.
What is this drug used for?
What do I need to tell my doctor BEFORE I take this drug?
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
- If you have an allergy to morphine sulfate or any other part of this drug.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Very bad lung problems like asthma or trouble breathing, high levels of carbon dioxide in the blood, or stomach or bowel block or narrowing.
- If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson’s disease like selegiline or rasagiline in the last 14 days. Taking this drug within 14 days of those drugs can cause very bad high blood pressure. Talk with your doctor.
- If you are taking any of these drugs: Buprenorphine, butorphanol, nalbuphine, or pentazocine.
What are some things I need to know or do while I take this drug?
- Tell dentists, surgeons, and other doctors that you use this drug.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
- Talk with your doctor before you use other drugs and natural products that slow your actions.
- Do not take this drug with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
- Have your blood work checked if you are on this drug for a long time. Talk with your doctor.
- If you are 65 or older, use this drug with care. You could have more side effects.
- If you have been taking this drug for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect. This is known as tolerance. Call your doctor if this drug stops working well. Do not take more than ordered.
- This drug may be habit-forming with long-term use.
- Do not stop taking this drug all of a sudden without calling your doctor. You may have a greater risk of signs of withdrawal. If you need to stop this drug, you will want to slowly stop it as ordered by your doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
- If you are allergic to sulfites, talk with your doctor. Some products have sulfites.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very bad dizziness or passing out.
- Chest pain or pressure or a fast heartbeat.
- Slow heartbeat.
- A heartbeat that does not feel normal.
- Trouble breathing, slow breathing, or shallow breathing.
- Change in thinking clearly and with logic.
- Mood changes.
- A burning, numbness, or tingling feeling that is not normal.
- Very bad headache.
- Very upset stomach or throwing up.
- Trouble passing urine.
- Swelling in the arms or legs.
- Very hard stools (constipation).
- Feeling very tired or weak.
- Sweating a lot.
- Any bruising or bleeding.
- Change in eyesight.
- Memory problems or loss.
- Very bad belly pain.
- Trouble walking.
- Trouble speaking.
What are some other side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling sleepy.
- Dry mouth.
- Upset stomach or throwing up.
- Hard stools (constipation).
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.
- You may see the tablet shell in your stool.
How is this drug best taken?
Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.
All oral products:
- Take with or without food. Take with food if it causes an upset stomach.
- To gain the most benefit, do not miss doses.
- Take this drug at the same time of day.
- Do not put this drug down a feeding tube.
- Do not use for fast pain relief or on an as needed basis.
- Do not use for pain relief after surgery if you have not been taking drugs like this drug.
- Measure liquid doses carefully. Use the measuring device that comes with this drug. If there is none, get an oral syringe, a dropper, a spoon, or a cup (only for older children) from your pharmacist.
- Measure liquid doses carefully. Use the measuring device that comes with this drug.
- Use suppository rectally.
- Wash your hands before and after use.
- If suppository is soft, chill in a refrigerator or run cold water over it.
- Take foil off the rectal suppository and put in, pointed end first. Do not handle too much.
- Wet suppository before putting in rectum.
- It is given as a shot.
- Your doctor may teach you how to use.
- Follow how to use carefully.
- Do not use if the solution is cloudy, leaking, or has particles.
- Do not use if solution changes color.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- Many times this drug is taken on an as needed basis. Do not take more often than told by the doctor.
Long-acting products and shot:
- Call your doctor to find out what to do.
How do I store and/or throw out this drug?
Oral products and suppository:
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Most of the time, this drug will be given in a hospital or doctor’s office. If stored at home, follow how to store as you were told by your doctor.
- Keep all drugs out of the reach of children and pets.
- Check with your pharmacist about how to throw out unused drugs.
General drug facts
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else’s drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
Consumer Information Use and Disclaimer
This information should not be used to decide whether or not to take this medicine or any other medicine. Only your healthcare provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your healthcare provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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