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Nafarelin (naf a REL in)

Adult Medication

Brand Names: U.S.

Synarel

Brand Names: Canada

Synarel®

What is this drug used for?

  • It is used to treat endometriosis.
  • It is used to delay puberty in children who are maturing too early.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to nafarelin or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have unexplained vaginal bleeding.
  • If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.
  • If you are breast-feeding. Do not breast-feed while you take this drug.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • Have your blood work checked often. Talk with your doctor.
  • This drug may affect certain lab tests. Be sure your doctor and lab workers know you take this drug.
  • It may take 2 months to see the full effect.
  • Use care if you have risks for heart disease (high blood pressure, high cholesterol, overweight, high blood sugar [diabetes], cigarette smoking, man older than 40 years of age, other family members with early heart disease, woman after change of life). Talk with your doctor.
  • Use care if you have risks for soft, brittle bones called osteoporosis (alcohol use, cigarette smoking, other family members with brittle bones, taking drugs to treat seizures, taking steroids).
  • This drug may cause weak bones (osteoporosis) with long-term use. Talk with your doctor to see if you have a higher chance of weak bones or if you have any questions.
  • Have a bone density test. Talk with your doctor.
  • Do not use a nose decongestant spray within 2 hours after using this drug.
  • Ovarian cysts may rarely happen in the first 2 months of therapy.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking this drug.
  • A pregnancy test will be done to show that you are NOT pregnant before starting this drug. If you get pregnant while taking this drug, call your doctor right away.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure.
  • Bad nose irritation.
  • Change in thinking clearly and with logic.
  • For women, still having a period.
  • Low mood (depression).
  • Mood changes.
  • A heartbeat that does not feel normal.
  • Seizures.
  • Shortness of breath.
  • Belly pain.
  • Swelling in the arms or legs.
  • Vaginal discharge.
  • Yellow skin or eyes.
  • Very bad vaginal bleeding.
  • Vaginal bleeding for more than 2 months.
  • Bone pain.
  • A very bad pituitary gland problem (pituitary apoplexy) has rarely happened with this drug. Most of the time, this has happened within 2 weeks after the first dose. Call your doctor right away if you have a sudden headache, throwing up, passing out, mood changes, eye weakness, not able to move your eyes, or change in eyesight.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Headache.
  • Flushing.
  • Pimples (acne).
  • Vaginal irritation.
  • Nose irritation.
  • Runny nose.
  • Emotional ups and downs.
  • Lowered interest in sex.
  • Short-term enlarged breasts.
  • If you are taking this drug to delay puberty, you may see short-term body odor or signs of puberty like vaginal bleeding, enlarged breasts, or more pubic hair during the first month of care. If these last or are very bad, call your doctor.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.
  • To gain the most benefit, do not miss doses.
  • Take as you have been told, even if you feel well.
  • Do not take this drug by mouth. Use in your nose only. Keep out of your mouth and eyes (may burn).
  • Prime pump before first use by spraying it 6 times or until you see a fine mist.
  • Blow your nose before use.
  • Do not sneeze during or right after using this drug.
  • Spray up the nose only. Do not spray onto the wall joining your two nostrils.
  • Clean every day.
  • Check your spray use with your doctor at each visit. Read and follow the facts on how to use the spray. Make sure you use the spray the right way.

What do I do if I miss a dose?

  • Use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses or extra doses.
  • If you miss 2 doses, call your doctor.

How do I store and/or throw out this drug?

  • Store upright at room temperature. Do not freeze.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

Copyright © 2014 Clinical Drug Information, LLC and Lexi-Comp, Inc.