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Nitroglycerin (nye troe GLI ser in)

Brand Names: U.S.

Minitran; Nitro-Bid; Nitro-Dur; Nitro-Time; Nitrolingual; NitroMist; Nitrostat; Rectiv

Brand Names: Canada

Minitran; Mylan-Nitro Sublingual Spray; Nitro-Dur; Nitroglycerin Injection, USP; Nitrol; Nitrostat; Rho-Nitro Pump Spray; Transderm-Nitro; Trinipatch

What is this drug used for?

Sublingual (under the tongue):

  • It is used to treat or prevent chest pain or pressure.

Spray:

  • It is used to treat or prevent chest pain or pressure.

Oral capsule:

  • It is used to prevent chest pain or pressure.

Skin: Ointment (topical):

  • It is used to prevent chest pain or pressure.

Rectal:

  • It is used to treat anal pain.

Patch:

  • It is used to prevent chest pain or pressure.

Shot:

  • It is used to treat high blood pressure.
  • It is used to help a weak heart.
  • It is used to treat chest pain or pressure.

All products:

  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to nitroglycerin or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Anemia, bleeding in the brain, raised pressure in the brain, head injury, or recent heart attack.
  • If you have very bad heart disease.
  • If you are taking any of these drugs: Avanafil, sildenafil, tadalafil, or vardenafil.

Patch:

  • If you have an allergy to adhesive.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • Have your blood pressure checked often. Talk with your doctor.
  • Have your blood work checked often. Talk with your doctor.
  • This drug may affect certain lab tests. Be sure your doctor and lab workers know you take this drug.
  • Talk with your doctor before you drink wine, beer, or mixed drinks.
  • If you have been taking this drug for a long time without a break, it may not work as well. This is known as tolerance. Be sure to have a “nitrate-free” period of time each day. Talk with your doctor if this drug stops working well. Do not take more than ordered.
  • This drug may be habit-forming with long-term use.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Patch:

  • The patch may have metal. Take off the patch before an MRI.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure lasting more than 15 minutes. Get emergency medical care right away.
  • Raised rate, time it lasts, or harshness of chest pain.
  • Very bad dizziness or passing out.
  • Very bad headache.
  • Fast or slow heartbeat.
  • Blurred eyesight.
  • Dry mouth.
  • Sweating a lot.
  • Pale skin.
  • Very upset stomach or throwing up.
  • Shortness of breath.
  • A heartbeat that does not feel normal.
  • Swelling in the arms or legs.
  • Feeling very tired or weak.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Headache. Most of the time it gets better after taking this drug for a week.
  • Dizziness.
  • Flushing.
  • Upset stomach or throwing up.

Patch:

  • Skin irritation.

Shot:

  • Irritation where the shot is given.

Sublingual (under the tongue):

  • Mouth tingling.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

All products:

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.

Sublingual (under the tongue):

  • Sit down before use.
  • Place under tongue and let melt all the way. Do not chew, suck or swallow tablet.
  • Wait 5 minutes. If chest pain or pressure is still present, put another tablet under tongue. If chest pain or pressure is still present after 5 minutes, place another tablet under tongue. Call 911 or arrange for a ride to the hospital. Do not drive yourself.

Spray:

  • Prime pump before first use.
  • Sit down before use.
  • Do not shake.
  • Spray on or under tongue.
  • Avoid swallowing after use.
  • Avoid rinsing mouth for 5 to 10 minutes after use.
  • Wait 5 minutes. If chest pain or pressure is still present, spray on or under tongue. If chest pain or pressure is still present after 5 minutes, spray on or under tongue. Call 911 or arrange for a ride to the hospital. Do not drive yourself.

Nitrolingual®:

  • If not used in 6 weeks prime pump by spraying it 1 time.

NitroMist™:

  • If not used in 6 weeks prime pump by spraying it 2 times.

Oral capsule:

  • Take with or without food.
  • Swallow whole. Do not chew, break, or crush.
  • Take with a full glass of water.
  • Do not use this drug to treat sudden chest pain. It will not help. Talk with your doctor.

Skin: Ointment (topical):

  • Do not take this drug by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • Wash your hands before and after use.
  • Use the applicator or dose-measuring paper to spread in a thin layer. Put on your chest or other area.
  • Do not use this drug to treat sudden chest pain. It will not help. Talk with your doctor.
  • This drug may stain clothing or fabric.

Rectal:

  • Wash your hands before and after use.
  • Cover your finger with plastic-wrap, a surgical glove, or a finger cot.
  • Use the dosing guide on the box to put the ointment on your covered finger.
  • Place the finger with the ointment on it into the anal canal up to the first finger joint.
  • Smear the ointment inside the anus.
  • You may also put the ointment on the outside of your anus.
  • Keep out of your mouth, nose, vagina, and eyes (may burn).

Patch:

  • Follow how to use as you have been told by your doctor or read the package insert.
  • Wash your hands before and after use.
  • Put patch on at the same time of day.
  • Put patch on clean, dry, healthy skin.
  • Put patch on a site without hair.
  • Wear only one patch at a time.
  • Put the patch in a new area each time you change the patch.
  • Do not use this drug to treat sudden chest pain. It will not help. Talk with your doctor.

Shot:

  • It is given as an infusion into a vein over a period of time.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.

What do I do if I miss a dose?

Sublingual (under the tongue):

  • This drug is taken on an as needed basis. Do not take more often than told by the doctor.
  • Take a missed dose as soon as you think about it.

Spray:

  • This drug is taken on an as needed basis. Do not take more often than told by the doctor.
  • Take a missed dose as soon as you think about it.

Shot:

  • Call your doctor to find out what to do.

All other products:

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

All products:

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Rectal:

  • Keep the tube tightly closed. Use within 8 weeks of first opening.

Sublingual (under the tongue):

  • Store sublingual tablets in the original container at room temperature. Keep the cap tightly closed. Throw away any part not used when the date on the bottle has been reached.

Spray:

  • This drug may catch on fire. Do not use near an open flame or while smoking.
  • Protect from heat.

Shot:

  • The shot will be given to you in a hospital or doctor’s office. You will not store it at home.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only your healthcare provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your healthcare provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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