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Norethindrone and Mestranol (nor eth IN drone & MES tra nole)

Pediatric Medication

Brand Names: U.S.

Necon® 1/50; Norinyl® 1+50

Brand Names: Canada

Ortho-Novum® 1/50


  • Do not smoke while taking birth control pills. Cigarette smoking raises the chance of very bad heart and blood-related side effects. This chance is higher with heavy smoking (15 or more cigarettes per day). Birth control pills do not stop the spread of diseases caused by having sex.
  • Sometimes drugs are not safe when you take them with certain other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your doctor about all the drugs you take.

What is this drug used for?

  • It is used to control monthly period (menstrual) cycle.
  • It is used to ease painful period (menstrual) cycles.
  • It is used to treat hormonal imbalance.
  • It is used to treat endometriosis.
  • It is used to prevent pregnancy.
  • It is used to treat pimples (acne).

Is it safe for my child to take this drug?

  • If you have an allergy to mestranol, norethindrone, or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Blood clots, breast cancer, diseased arteries in the brain, disease of a heart valve with problems, endometrial cancer, heart disease, high blood pressure, liver disease, liver tumor, very bad headache, tumor where estrogen makes it grow, or vaginal bleeding.
  • If you have not started your period.
  • If you turned yellow during pregnancy or with estrogen-based or hormone contraceptive use.
  • If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.

What are some things I need to know or do while my child takes this drug?

  • If you have a family history of blood clots, talk with your doctor.
  • If you have heart disease, talk with your doctor.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • If you have migraine headaches, talk with your doctor.
  • Have your blood pressure and heart rate checked often. Talk with your doctor.
  • Have an eye exam every year.
  • Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • If you are taking a blood thinner, have your blood work checked. Talk with your doctor.
  • Tell dentists, surgeons, and other doctors that you use this drug.
  • Take good care of your teeth. See a dentist often.
  • Do not take St John’s wort, dong quai, black cohosh, saw palmetto, red clover, or ginseng with this drug.
  • If you are taking this drug and have high blood pressure, talk with your doctor before using OTC products that may raise blood pressure. These include cough or cold drugs, diet pills, stimulants, ibuprofen or like products, and some natural products or aids.
  • This drug does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my child’s doctor about right away?

  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
  • If your child shows signs of a very bad reaction, call your child’s doctor or the ER right away. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; swelling of face, lips, tongue, or throat; or if your child is not acting normal.
  • Chest pain or pressure.
  • Trouble breathing.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Very bad headache.
  • Very bad belly pain.
  • Very upset stomach or throwing up.
  • Not able to eat.
  • Dark urine or yellow skin or eyes.
  • Change in how contact lenses feel in the eyes.
  • Sudden change in eyesight, eye pain, or irritation.
  • A lump in the breast or breast soreness.
  • If you get pregnant while taking this drug.
  • Any rash.
  • Side effect or health problem is not better or you are feeling worse.

What are some other side effects of this drug?

  • Headache.
  • Belly pain.
  • Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
  • Period (menstrual) changes. These include spotting between cycles or very light periods.
  • Mood changes.
  • Swelling.
  • Enlarged breasts.
  • Vaginal yeast infection. Report itching or discharge.
  • Blood clots may rarely happen.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read and follow the dosing on the label closely.
  • Follow how to use as you have been told by your doctor or read the package insert.
  • Take this drug at the same time of day.
  • Take with or without food. Take with food if it causes an upset stomach.
  • If you are taking this drug to prevent pregnancy and miss 2 periods in a row, take a pregnancy test before starting a new dosing cycle.

What do I do if my child misses a dose?

  • Take a missed dose as soon as you think about it and go back to your normal time.
  • Missed dosing facts may be found in the package insert or call your doctor to find out what to do.

How do I store and/or throw out this drug?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.


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