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Pazopanib (paz OH pa nib)

Adult Medication

Brand Names: U.S.

Votrient

Brand Names: Canada

Votrient

Warning

  • Very bad and sometimes deadly liver problems have happened with this drug. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

What is this drug used for?

  • It is used to treat kidney cancer.
  • It is used to treat soft tissue sarcoma.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to pazopanib or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease.
  • If you are taking any of these drugs: Carbamazepine, cimetidine, dexamethasone, dexlansoprazole, esomeprazole, famotidine, lansoprazole, nevirapine, nizatidine, omeprazole, oxcarbazepine, pantoprazole, phenobarbital, phenytoin, primidone, rabeprazole, ranitidine, rifabutin, rifampin, rifapentine, or St. John’s wort.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with this drug. Talk with the doctor.
  • Very bad and sometimes deadly holes in the GI (gastrointestinal) tract or fistulas have happened with this drug. Talk with the doctor.
  • Very bad and sometimes deadly bleeding problems have happened with this drug. Talk with the doctor.
  • Blood clots have happened with this drug. Sometimes, blood clots like heart attack and stroke have been deadly. Talk with the doctor.
  • Tell your doctor if you are taking any other cancer drugs. The chance of very bad and sometimes deadly side effects may be raised. Talk with your doctor.
  • High blood pressure may rarely happen.
  • Have your blood pressure checked often. Talk with your doctor.
  • Have your blood work checked often. Talk with your doctor.
  • Have a heart function test. Talk with your doctor.
  • Have your urine checked. Talk with your doctor.
  • Avoid grapefruit and grapefruit juice.
  • This drug may affect how wounds heal. If you need to have surgery, you may need to stop this drug before surgery. Start taking it again after surgery as you have been told by your doctor. Talk with your doctor.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • This drug is not approved for use in children. Talk with the doctor.
  • This drug may cause harm to the unborn baby if you take it while you are pregnant.
  • Use birth control that you can trust to prevent pregnancy while taking this drug.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Chest pain or pressure.
  • A heartbeat that does not feel normal.
  • A fast heartbeat.
  • Very bad dizziness or passing out.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Change in thinking clearly and with logic.
  • Loss of eyesight.
  • Very bad belly pain.
  • Very upset stomach or throwing up.
  • Feeling very tired or weak.
  • Seizures.
  • Not able to pass urine or change in how much urine is passed.
  • Redness or irritation of the palms of hands or soles of feet.
  • Swelling of belly.
  • Heart failure has happened with this drug, as well as heart failure that has gotten worse in people who already have it. Tell your doctor if you have heart disease. Call your doctor right away if you have shortness of breath, a big weight gain, a heartbeat that is not normal, or swelling in the arms or legs that is new or worse.
  • A very bad and sometimes deadly blood problem called thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) has happened with this drug in some people. Call your doctor right away if you have any bruising or bleeding; feel very tired or weak; have dark urine or yellow skin or eyes; pale skin; change in the amount of urine passed; change in eyesight; change in strength on 1 side is greater than the other, trouble speaking or thinking, or change in balance; or fever.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Feeling tired or weak.
  • Headache.
  • Dizziness.
  • Belly pain.
  • Upset stomach or throwing up.
  • Loose stools (diarrhea).
  • Not hungry.
  • Change in taste.
  • Mouth irritation or mouth sores.
  • Change in color of hair.
  • Hair loss.
  • Muscle pain.
  • Weight loss.
  • Not able to sleep.
  • Change in nails.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.
  • Take as you have been told, even if you feel well.
  • To gain the most benefit, do not miss doses.
  • Take on an empty stomach. Take 1 hour before or 2 hours after meals.
  • Swallow whole. Do not chew, break, or crush.
  • Do not take antacids at the same time as this drug. Talk with your doctor.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is less than 12 hours until the next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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