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Pegaspargase (peg AS par jase)

Pediatric Medication

Brand Names: U.S.

Oncaspar

What is this drug used for?

  • It is used to treat leukemia.

Is it safe for my child to take this drug?

  • Not if your child has an allergy to pegaspargase or any other part of this drug.
  • Be sure to let the doctor know if your child has any allergies or side effects to drugs, foods, or dyes. Make sure to tell about the allergy and what signs your child had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • Not if your child has any irritation of the pancreas.
  • Not if your child has had bleeding, a blood clot, or an irritated pancreas when using asparaginase in the past.

What are some things I need to know or do while my child takes this drug?

  • Tell dentists, surgeons, and other doctors that your child is using this drug.
  • If your child has a blood clotting problem, talk with the doctor.
  • If your child has liver disease, talk with the doctor.
  • If your child has pancreatic disease, talk with the doctor.
  • Have your child’s blood work checked often. Talk with your child’s doctor.
  • If your child has high blood sugar (diabetes), talk with the doctor. This drug can raise blood sugar.
  • Have your child’s blood sugar checked as you have been told by your child’s doctor.
  • Check all drugs your child is taking with your child’s doctor. This drug may not mix well with some other drugs.
  • Talk with your child’s doctor about giving you an EpiPen® to treat a bad allergic reaction after you have left the health center.
  • Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
  • Your child may bleed or clot more easily. Have him/her be more careful and avoid injury. Keep your child from rough-housing or playing contact sports.
  • Talk with the doctor before giving your child products that have aspirin, ibuprofen or like products, blood thinners (warfarin, ticlopidine, clopidogrel), garlic, ginseng, ginkgo, or vitamin E.
  • Unsafe allergic effects may happen. Your child will be closely watched while taking this drug.

If your child is pregnant or breast-feeding a baby:

  • Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. You will need to talk about the benefits and risks of using this drug.

What are some side effects that I need to call my child’s doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child’s doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Irritation or swelling where the shot was given.
  • If your child has shortness of breath.
  • If your child has chest pain or pressure.
  • If your child has a change in thinking clearly and with logic.
  • If your child has a bad headache.
  • If your child has any bruising or bleeding.
  • Coughing up blood.
  • If your child has a change in eyesight.
  • If your child gets a rash.
  • Signs of a pancreas problem (pancreatitis) like very bad stomach pain, very bad back pain, or very bad upset stomach or throwing up.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away:
  • Upset stomach or throwing up. Many small meals and good mouth care may help. Older children may suck hard, sugar-free candy.
  • Bleeding problems.
  • Clotting problems.
  • Swelling.
  • Irritated pancreas.
  • Allergic side effects may rarely happen.
These are not all of the side effects that may occur. If you have questions about side effects, call your child’s doctor. Call your child’s doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best given?

Give this drug as ordered by your child’s doctor. Read and follow the dosing on the label closely.
  • It is given as a shot into a muscle or vein.

What do I do if my child misses a dose?

  • Call your child’s doctor to find out what to do.

How do I store and/or throw out this drug?

  • This drug will be given to your child in a hospital or doctor’s office. You will not store it at home.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your child’s symptoms or health problems do not get better or if they become worse, call your child’s doctor.
  • Do not share your child’s drug with others and do not give anyone else’s drug to your child.
  • Keep a list of all your child’s drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child’s doctor.
  • Talk with your child’s doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your child’s doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Last Reviewed Date

2014-05-30

Copyright

Copyright © 2014 Clinical Drug Information, LLC and Lexi-Comp, Inc.