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Progesterone (proe JES ter one)

Adult Medication

Brand Names: U.S.

Crinone; Endometrin; First-Progesterone VGS 100; First-Progesterone VGS 200; First-Progesterone VGS 25; First-Progesterone VGS 400; First-Progesterone VGS 50; Prometrium

Brand Names: Canada

Crinone; Endometrin; Prometrium

Warning

  • Do not use estrogens to prevent heart disease or dementia. Using estrogens may raise the chances of having a heart attack, a stroke, breast cancer, a blood clot, or dementia.
  • Use estrogens with or without progestin for the shortest time needed at the lowest useful dose.

What is this drug used for?

  • It is used in in vitro fertilization.
  • It is used to lower the chance of endometrial changes in women after change of life who are getting estrogen therapy.
  • It is used to treat uterine bleeding due to hormonal imbalance.
  • It is used to treat women who do not have a monthly period cycle.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take this drug?

  • If you have an allergy to progesterone or any other part of this drug.
  • If you have a peanut allergy and are taking the capsules. The capsules have peanut oil in them.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have had any of these health problems: Bleeding disorder; blood clots or risk of having a blood clot; breast cancer; cancer of the uterus, ovary, cervix, or vagina; liver disease; recent heart attack; recent stroke; or vaginal bleeding where the cause is not known.

Capsule:

  • If you are pregnant or may be pregnant. Do not take this drug if you are pregnant.

Gel, vaginal insert, or shot:

  • If you have had a recent miscarriage.

Vaginal insert:

  • If you are using any other vaginal products.
  • If you have a pregnancy that is not inside the uterus (ectopic pregnancy).
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • If you have an allergy to any type of nuts or seeds, talk with your doctor. Some products have nuts in them.
  • If you have high blood sugar (diabetes), talk with your doctor. This drug may raise blood sugar.
  • Do monthly breast self-exams and have a gynecologic exam every year.
  • This drug may affect certain lab tests. Be sure your doctor and lab workers know you take this drug.
  • Talk with your doctor if you will need to be still for long periods of time like long trips, bed rest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • This drug is not approved for use in children. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure.
  • Shortness of breath.
  • Coughing up blood.
  • Change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or blurred eyesight.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Trouble walking.
  • Very bad headache.
  • Very upset stomach or throwing up.
  • Very bad dizziness or passing out.
  • Bulging eyes.
  • Change in eyesight.
  • A lump in the breast, breast soreness, or nipple discharge.
  • Breast pain.
  • Vaginal itching or discharge.
  • Vaginal bleeding that is not normal.
  • Pain when passing urine.
  • Passing urine often.
  • Low mood (depression).
  • Mood changes.
  • Memory problems or loss.
  • Seizures.
  • Swelling in hands or feet.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

Vaginal insert:

  • Pelvic pain.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
  • Dizziness.
  • Feeling sleepy.
  • Not able to sleep.
  • More hungry.
  • Hard stools (constipation).
  • Headache.
  • Hair loss.
  • Upset stomach or throwing up.
  • Belly pain.
  • Cramps.
  • Bloating.
  • Loose stools (diarrhea).
  • Enlarged breasts.
  • Breast soreness.
  • Muscle pain.
  • Back pain.
  • Feeling tired or weak.
  • Vaginal bleeding or spotting.
  • Lowered interest in sex.

Gel or vaginal insert:

  • Vaginal irritation.

Shot:

  • Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.

Capsule:

  • Follow how to use as you have been told by your doctor or read the package insert.
  • Take with or without food. Take with food if it causes an upset stomach.
  • Take with a full glass of water.
  • If you have trouble swallowing, talk with your doctor.

Shot:

  • It is given as a shot into a muscle.

Vaginal:

  • Follow how to use as you have been told by your doctor or read the package insert.
  • Wash hands before and after use.
  • Do not take other vaginal drugs within 6 hours of this drug.

What do I do if I miss a dose?

Shot:

  • Call the doctor to find out what to do.

All other products:

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

How do I store and/or throw out this drug?

Shot:

  • This drug will be given to you in a hospital or doctor’s office. You will not store it at home.

All other products:

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

Copyright © 2014 Clinical Drug Information, LLC and Lexi-Comp, Inc.