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Selegiline (se LE ji leen)

Adult Medication

Brand Names: U.S.

Eldepryl; Emsam; Zelapar

Brand Names: Canada

Apo-Selegiline; Gen-Selegiline; Mylan-Selegiline; Novo-Selegiline; Nu-Selegiline

Warning

Skin patch:

  • Children and teens who take this drug may be at a greater risk of having thoughts or actions of suicide. Adults may also be at risk. The risk may be greater in people who have had these thoughts or actions in the past. Watch people who take this drug closely. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
  • This drug is not approved for use in children. Talk with the doctor.
  • Do not give to a child younger than 12 years of age.

What is this drug used for?

  • It is used to treat Parkinson’s disease.
  • It is used to treat low mood (depression).

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to selegiline or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have pheochromocytoma.
  • If you are using another drug that has the same drug in it.
  • If you are taking any of these drugs: Dextromethorphan, meperidine, methadone, propoxyphene, tramadol, or another narcotic (opioid) drug.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like certain drugs that are used for low mood (depression) or other mood problems, seizures, weight loss, and the common cold. There are many drugs that must not be taken with this drug.
  • If you are having surgery, talk with your doctor.

Oral-disintegrating tablet:

  • If you have any of these health problems: Kidney disease or liver disease.
This is not a list of all drugs or health problems that interact with this drug.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • Do not stop taking this drug all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop this drug, you will want to slowly stop it as ordered by your doctor.
  • Have your blood pressure and heart rate checked often. Talk with your doctor.
  • Some foods and drinks like cheese and red wine, when taken with higher doses of this drug, may cause very bad and sometimes deadly effects such as sudden high blood pressure. Talk with your doctor about your risk for these effects. Get a list of foods to avoid.
  • The chance of a type of skin cancer called melanoma may be raised in people with Parkinson’s disease. It is not known if this drug may also raise the chance. Have skin exams while you take this drug. Talk with your doctor.
  • Talk with your doctor before you drink wine, beer, or mixed drinks.
  • Some people taking the oral form of this drug have fallen asleep during activities like driving, eating, or talking. Some people did not feel sleepy and felt alert right before falling asleep. This has happened up to 1 year after this drug was started. If you fall asleep during activities, do not drive or do other tasks or actions that call for you to be alert while you take this drug. Call your doctor right away if this happens or you feel very sleepy.
  • If you are 65 or older, use this drug with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Oral-disintegrating tablet:

  • If you have PKU, talk with your doctor. Some products have phenylalanine.

Skin patch:

  • Avoid use of heat sources (such as sunlamps, tanning beds, heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds). Avoid long, hot baths or sunbathing. Your temperature may rise and cause too much drug to pass into your body.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
  • Shakiness, trouble moving around, or stiffness.
  • Very bad headache.
  • Very bad dizziness or passing out.
  • Change in thinking clearly and with logic.
  • Mood changes.
  • Change in how you act.
  • Hallucinations.
  • Change in balance.
  • Strong urges that are hard to control (such as gambling or sex).
  • A skin lump or growth.
  • Change in color or size of a mole.
  • Chest pain or pressure.
  • Muscle pain or weakness.
  • Neck stiffness.

Oral-disintegrating tablet:

  • Mouth sores.
  • Very bad pain when swallowing.

Skin patch:

  • Very bad skin irritation.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Dizziness.
  • Feeling sleepy.
  • Headache.
  • Dry mouth.
  • Upset stomach or throwing up.
  • Not able to sleep.
  • Loose stools (diarrhea).
  • Back pain.
  • Runny nose.
  • Stuffy nose.

Oral-disintegrating tablet:

  • Mouth irritation.

Skin patch:

  • Skin irritation.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.

All products:

  • Use as you have been told, even if you feel well.

Tablets and capsules:

  • Take this drug with food.

Oral-disintegrating tablet:

  • Take before breakfast.
  • Do not remove the tablet from the tablet pack until you are ready to take this drug. Take the tablet right away after opening the blister pack. Do not store the removed tablet for future use.
  • Do not push the tablet out of the foil when opening. Use dry hands to take it from the foil. Place on your tongue and let it melt. Water is not needed. Do not swallow it whole. Do not chew, break, or crush it.
  • Do not eat or drink for at least 5 minutes before or after taking this drug.

Skin patch:

  • Wash your hands before and after use.
  • Put patch on clean, dry, healthy skin on the chest, back, upper leg, or upper arm.
  • Do not use patches that are cut or do not look right.
  • Put the patch in a new area each time you change the patch.
  • Wear only one patch at a time.
  • If the patch falls off, replace with a new one on a new site.
  • After you take off a skin patch, be sure to fold the sticky sides of the patch to each other.

What do I do if I miss a dose?

  • Use a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not use 2 doses or extra doses.

How do I store and/or throw out this drug?

All products:

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Oral-disintegrating tablet:

  • Use oral disintegrating tablets within 3 months of opening pouch.

Skin patch:

  • Store patches in pouch until ready for use.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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