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Treprostinil (tre PROST in il)

Adult Medication

Brand Names: U.S.

Orenitram; Remodulin; Tyvaso; Tyvaso Refill; Tyvaso Starter

Brand Names: Canada

Remodulin

What is this drug used for?

  • It is used to treat high pressure in the lungs.

What do I need to tell my doctor BEFORE I take this drug?

All products:

  • If you have an allergy to treprostinil or any other part of this drug.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.

Tablets:

  • If you have liver disease.
This drug may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take this drug?

All products:

  • Tell dentists, surgeons, and other doctors that you use this drug.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • Do not stop taking this drug all of a sudden. Signs of high pressure in the lungs like shortness of breath, dizziness, or weakness may get worse. Talk with your doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Tablets:

  • Avoid beer, wine, or mixed drinks.
  • The tablet shell does not melt. If you have a certain stomach problem (diverticulitis), this may be a problem. Talk with your doctor.

Shot:

  • Always have a backup system close by in case you need to use it.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

All products:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Very bad dizziness or passing out.
  • Shortness of breath, a big weight gain, swelling in the arms or legs.

Tablets:

  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.

Shot:

  • A burning, numbness, or tingling feeling that is not normal.
  • Pain and irritation where this drug goes into the body.

Liquid for breathing in:

  • Cough that does not go away.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

All products:

  • Headache.
  • Flushing.
  • Jaw pain.
  • Dizziness.
  • Loose stools (diarrhea).
  • Upset stomach.

Tablets:

  • Pain in arms or legs.
  • Stomach pain.
  • You may see the tablet shell in your stool.

Liquid for breathing in:

  • Cough.
  • Throat irritation.
  • Muscle pain.
  • Bone pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to your national health agency.

How is this drug best taken?

Use this drug as ordered by your doctor. Read and follow the dosing on the label closely.

All products:

  • Follow how to take this drug as you have been told by your doctor. Do not use more than you were told to use.

Tablets:

  • Take this drug with food.
  • Swallow whole. Do not chew or crush.
  • Do not split or break tablet.
  • Do not take chipped or broken tablets.

Shot:

  • It is given into the vein or the fatty part of the skin nonstop.
  • Your doctor may teach you how to give this drug.
  • Follow how to use carefully.
  • Wash your hands before and after use.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Throw away needles in a needle/sharp disposal box. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

Liquid for breathing in:

  • For breathing into the lungs only using the Tyvaso™ inhalation system.
  • After the last dose is used for the day, get rid of any drug that is left in the chamber so it is ready for the next day.
  • Have your puffer (inhaler) use checked with your doctor at each visit. Read and follow facts on how to use the puffer. Make sure you use the puffer the right way.
  • Do not mix other drugs in nebulizer.
  • If you get this drug in your eyes or on your skin, rinse with water.

What do I do if I miss a dose?

Shot:

  • Call the doctor to find out what to do.

Liquid for breathing in:

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

Tablets:

  • Take a missed dose as soon as you think about it, with food.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you miss 2 doses, call your doctor.

How do I store and/or throw out this drug?

Shot:

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Throw away any part of opened vial not used after 1 month.

All other products:

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.

Liquid for breathing in:

  • Store unused containers in foil pouch until use.
  • Protect from light.
  • Throw away any part of opened pouch that is not used after 7 days.

All products:

  • Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

General drug facts

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else’s drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Consumer Information Use and Disclaimer

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Copyright

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