The purpose of this study is to see if giving hyperthermic intraperitoneal chemotherapy (HIPEC) during surgery, followed by standard postoperative chemotherapy, is more effective than standard postoperative chemotherapy without HIPEC for women with recurrent ovarian, fallopian tube, or primary peritoneal cancer who are having a second surgery to remove cancerous tissue in the abdomen.
HIPEC involves giving heated carboplatin (a standard drug for these cancers) directly into the abdomen at the end of a patient’s surgery. It is believed that heating the carboplatin may make it better able to penetrate and kill cancer cells.
All patients will have the surgery followed by standard postoperative chemotherapy. Patients will be randomly assigned to receive HIPEC at the end of surgery or not. Researchers will compare the incidence of recurrence and side effects between the two groups.