MEK162 and LEE011 are investigational anticancer drugs being assessed together in this study in patients with melanoma. MEK162 blocks a protein called MEK, which can cause melanoma to grow. LEE011 blocks a protein called CDK, which tells melanoma cells to divide.
The abnormal (mutated) form a protein called NRAS increases the growth of melanoma. Another clinical trial showed that MEK162 helped some patients with NRAS-mutant melanoma. Laboratory studies have suggested that MEK162 may be more effective against NRAS-mutant melanoma when it is given with LEE011.
The purpose of this study is to assess the safety and effectiveness of the combination of LEE011 and MEK162 when given in patients with locally advanced or metastatic NRAS-mutant melanoma. Both drugs are taken orally (by mouth).