A Phase II Study of Cabozantinib in Patients with Advanced Non-Small Cell Lung Cancer

Protocol
12-097
Full Title
A Phase II Study of Cabozantinib in Patients with KIF5B/RET Positive Advanced Non-Small Cell Lung Cancer
Phase
II
Purpose

KIF5B/RET is an abnormal gene that leads to the growth of lung cancer cells. Cabozantinib is an investigational drug that inhibits the effects of this gene. In addition, this drug interferes with other pathways that also cause cancer cells to grow, form new blood vessels, and spread to other parts of the body.

In this study, researchers are evaluating the safety and effectiveness of cabozantinib in patients with advanced non-small cell lung cancers that contain the KIF5B/RET gene. Cabozantinib is a pill that is taken orally (by mouth).

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

For more information and to inquire about eligibility for this study, please contact Dr. Alexander Drilon at 646-888-4206.

Disease(s)
Lung Cancer
Lung Cancer, Non-Small Cell
Lung Cancer, Non-Small Cell: Lung Adenocarcinoma
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