Cisplatin is a chemotherapy drug commonly used to treat germ cell tumors. One of the long-term side effects of cisplatin is thought to be heart disease, although the way cisplatin causes heart disease is not well understood. One possible way is through damage caused by cisplatin to the inner layer of blood vessels called the endothelium.
The purpose of this study is to measure changes in the endothelium in men with germ cell tumors who are receiving cisplatin, and to compare these changes to those in patients with germ cell tumors who are having surgery alone and not receiving chemotherapy. Participants in this study have the health of the endothelium measured before and after treatment (for patients receiving cisplatin) or at different time points (for those treated with surgery alone).