ALTE03N1: Key Adverse Events Following Childhood Cancer

Full Title
Key Adverse Events after Childhood Cancer ALTE03N1 (COG)

People who have been treated for cancer as children have an increased risk of developing adverse “events” later in life, such as heart problems, stroke, and second cancers. The goals of this study are to look at how late-effects develop among patients who have gone through treatment for childhood cancer; to see how late-effects relate to the type of cancer, stage of cancer, and treatment; and to compare cancer survivors who have a late-effect to those who do not have a late-effect, but who had the same type of cancer and treatment, length of time since diagnosis, and race.

By comparing these two groups of individuals, researchers want to see if certain individuals, cancer treatments, or genes are related to an increased risk of developing a late-effect.


To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • All participants must have been diagnosed with cancer before age 21.
  • Participants must have had a heart attack; congestive heart failure (a damaged heart that is unable to move blood efficiently); avascular necrosis (poor blood supply to an area of the bone that causes permanent bone damage); a stroke; or a second cancer.

For more information about this study, please contact Dr. Charles Sklar at 212-639-8138.


Cancer Clinical Trials: Personalizing for Each Patient

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