A Phase II Trial of Chemotherapy Plus Cetuximab Followed by Surgery in Patients with Locally Advanced Thymoma

Protocol
09-038
Full Title
A Phase II Trial of Chemotherapy Plus Cetuximab Followed by Surgical Resection in Patients with Locally Advanced or Recurrent Thymoma or Thymic Carcinoma (BMS#CA225-331)
Phase
II
Purpose

Surgery is often used to treat thymomas, and giving chemotherapy before surgery can help treat the disease in advanced cases and raise the chance of surgery being successful. The purpose of this study is to assess the safety and effectiveness of giving combination chemotherapy plus cetuximab before surgery in patients with thymoma to see if this treatment increases the chance of a cure.

Cisplatin, doxorubicin, and cyclophosphamide are commonly used to treat thymoma. Cetuximab will be added to this regimen before surgery. Cetuximab is approved for the treatment of advanced colorectal and head and neck cancers, but its use for thymoma is considered investigational.

It is thought that thymomas might respond to cetuximab because they contain a protein called epidermal growth factor receptor. Cetuximab works by blocking this receptor and preventing cancer cells from receiving the message to grow and multiply.

Researchers will also look at changes in genes in the tumor that may be related to the effectiveness of cetuximab.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have previously untreated locally advanced thymoma that has not metastasized.
  • Patients must be age 18 or older.

For more information and to inquire about eligibility for this study, please contact Dr. James Huang at 646-888-3055.

Disease(s)
Thymoma

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