The purpose of this study is to evaluate three different prostate cancer treatment regimens for men whose prostate was surgically removed but whose PSA level continues to rise:
- radiation therapy to the prostate bed (the area where the prostate was located before it was removed)
- hormone therapy for 4 to 6 months plus radiation therapy to the prostate bed
- hormone therapy for 4 to 6 months plus radiation therapy to the prostate bed and to the pelvic lymph nodes.
There is some evidence in men who have not had surgery that radiotherapy to the pelvic lymph nodes may stop prostate cancer from spreading under some conditions. Since treating the pelvic lymph nodes can result in increased side effects, the benefit of this method of radiation therapy needs to be tested.
Some patients treated with hormonal therapy and radiation therapy have a reduced risk of recurrence compared to men treated with radiation alone.