Protocol
10-086
Full Title
A Phase I/IIa Study of Safety and Efficacy Of Alpharadin® With Docetaxel In Patients With Bone Metastases From Castration-Resistant Prostate Cancer
Purpose
Docetaxel is a chemotherapy drug commonly used in men with advanced prostate cancer that continues to grow and spread despite hormonal therapies (“castration-resistant” prostate cancer). The purpose of this study is to establish the optimal dose of and evaluate the effectiveness of a drug called Alpharadin when given in combination with docetaxel in men with bone metastases from castration-resistant prostate cancer.
Alpharadin is radium-223 chloride, a liquid that contains a radioactive element that specifically targets prostate cancer that has spread (metastasized) to bone. The radiation that radium-223 gives out travels only a very short distance in the body, and therefore acts mainly on the areas of the bones that require treatment: bone metastases.
Investigator
Co-Investigators
Eligibility
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have two or more bone metastases from castration-resistant prostate cancer.
- Patients’ PSA levels must be 2 ng/mL or more, and testosterone levels must be 50 ng/dL or less.
- At least 4 weeks must have passed since completion of prior therapy and entry into the study.
- Patients must be age 18 or older
For more information about this study and to inquire about eligibility, please contact Dr. Michael Morris at 646-422-4469.
Disease(s)
Prostate Cancer
Prostate Cancer: Metastatic Disease after Hormone-Reducing Therapy
Locations
ClinicalTrials.gov
Related Diseases
