A Phase II Study of PD0332991 in Patients with Advanced or Metastatic Liposarcoma

Protocol
10-094
Full Title
A Phase II Study of PD0332991 in Patients with Advanced or Metastatic Liposarcoma
Phase
II
Purpose

The purpose of this study is to determine the safety and effectiveness of an investigational drug called PD0332991 in patients with metastatic or recurrent liposarcoma. PD0332991 blocks a protein called CDK4, which is part of a pathway in liposarcoma cells that is overactive. Researchers hope that blocking CDK4 will shut down this pathway in liposarcoma cells and stop tumors from growing. PD0332991 is an oral medication (taken by mouth).

Co-Investigators

Schwartz, Gary, MD

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have a confirmed diagnosis of metastatic or recurrent liposarcoma that cannot be surgically removed.
  • Patients’ tumors must express the Rb protein and show evidence of amplified CDK4.
  • Patients must have had at least one regimen of chemotherapy for recurrent/metastatic disease.
  • At least 2 weeks must have passed since completion of chemotherapy and entry into the study.
  • Patients must be physically well enough that they are fully ambulatory, capable of all self care, and are capable of all but physically strenuous activities. As an example, patients must be well enough that they would be able to carry out office work or light housework.
  • Patients must be age 18 or older.

For more information about this study and to inquire about eligibility, please contact Dr. Mark A. Dickson at 646-888-4166.

Disease(s)
Sarcomas
Sarcomas: Soft Tissue Sarcoma
Locations
Related Diseases