Kaposi’s sarcoma (KS) is a type of cancer that is very common in people with AIDS. Treatments for KS do not cure the disease, and better treatments are needed.
The purpose of this study is to evaluate the effectiveness of bortezomib in patients with AIDS-related KS. Bortezomib is used to treat cancers called multiple myeloma and mantle cell lymphoma. Its use in people with KS is considered investigational.
Bortezomib may help stop HIV from progressing and stop the growth of cancer cells. It may also cause the KS herpes virus that lives in KS tumor cells to enter an active state that kills the tumor cells.