Protocol
10-152
Full Title
A Phase II Study Of Repeat Breast Preserving Surgery and 3d-Conformal Partial Breast Re-Irradiation (PBRI) For Local Recurrence of Breast Carcinoma (RTOG 1014)
Purpose
When a second cancer is found in a breast that was already treated with lumpectomy followed by radiation to the whole breast, the standard treatment is a mastectomy. Very few studies have been done to find out if breast conservation therapy (repeat lumpectomy and re-irradiation to part of the breast) can be used as an alternative to mastectomy.
The purpose of this study is to evaluate the side effects of partial breast re-irradiation given after a lumpectomy. The lumpectomy will be done to remove the breast cancer and a limited amount of surrounding normal breast tissue. Following the surgery, patients will receive three-dimensional conformal radiation therapy (3D-CRT) to treat only the area in the breast where the lumpectomy was performed. 3D-CRT tries to lower the amount of radiation that normal tissues receive, while still delivering the desired amount of radiation to the cancer and to areas that may contain cancer cells.
Investigator
Eligibility
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Patients must have a recurrence of cancer in a breast that was previously treated for breast cancer with lumpectomy and radiation more than 1 year before entering the study.
- The recurrent tumor must be 3cm or less in size.
- Patients must have had bilateral mammography and MRI within 4 months of entering the study.
- For patients who have had chemotherapy, at least 2 weeks must have passed since the last dose of treatment and entry into the study.
- Patients must be age 18 or older.
For more information about this study and to inquire about eligibility, please contact Dr. Beryl McCormick at 212-639-6828 or Dr. Alice Ho at 212-639-6773.
Disease(s)
Breast Cancer
Locations
Related Diseases
