The purpose of this study is to find out which way of giving high-dose radiation therapy works best for the treatment of cancer that has spread. This study will look at the safety and effectiveness of giving 27 Gy of radiation in three fractions of 9 Gy each (over five days) or 24 Gy in one fraction (in one day) using image-guided intensity-modulated radiotherapy (IG-IMRT).
IG-IMRT is radiation that is given directly to the cancer site, and reduces the exposure to nearby normal tissue. Currently there are no studies that compare the side effects and effectiveness of giving radiation in either hypofractionated doses (higher total doses of radiation spread out over several treatment days) or a single-fraction dose (entire radiation dose given in one treatment session) in patients with metastatic cancer.
Patients in this study will be randomly assigned to receive either 27 Gy over five days or 24 Gy in one day.