Patients who have recurrent ovarian, fallopian tube, or peritoneal cancer are often treated with several drugs. Carboplatin is one that seems to work for many treatment cycles. Even though it may work against the cancer, patients can become allergic to it. If that happens, treatment with the drug usually needs to be stopped.
Some patients have received carboplatin over three hours instead of 30 minutes. They had fewer allergic reactions than expected. Doctors do not know if this was because of the way they got carboplatin or because of some other factor.
The purpose of this study is to see if giving carboplatin over three hours prevents allergic reactions to the drug, and to see if giving certain other medications before the carboplatin can help reduce allergies. Some patients may receive other chemotherapy drugs as part of their treatment in addition to carboplatin.