Carboplatin and paclitaxel are standard drugs used to treat many types of cancer. BKM120 is an investigational drug that blocks a molecule called PI3 kinase, which appears to function abnormally in many cancers.
The goal of this study is to establish the highest dose of BKM120 that can be given safely with paclitaxel and carboplatin in patients with advanced solid tumors. All patients will be treated with standard doses of carboplatin and paclitaxel. Patients will be enrolled to receive treatment with one of three possible doses of BKM120.
BKM120 is taken orally (by mouth).