Prostate cancers initially need the male hormone testosterone for growth. Hormone therapies that lower the level of testosterone are among the most effective treatments for prostate cancers that have spread to other organs (metastasized). The benefits of hormone treatments do not last, however. Over time, many prostate cancers continue to grow despite hormonal therapies (“castration-resistant” prostate cancer).
Anticancer drugs such as docetaxel and cabazitaxel may be used in men with castration-resistant disease. But while these drugs can slow cancer growth, they do not cure the cancer. Doctors are therefore continuing to search for more effective treatments for men with advanced prostate cancer.
The purpose of this study is to find the highest dose of an investigational drug called DSTP3086S that can be given safely in men with metastatic castration-resistant prostate cancer who cannot be treated with standard therapy or who elect not to have standard chemotherapy. DSTP3086S is an antibody bound to a chemotherapy drug. The antibody targets prostate cancer cells, and delivers the anticancer drug directly to those cells to kill them.