PU-H71 is an investigational drug that works by blocking a protein called Heat Shock Protein 90 (Hsp90). Attacking Hsp90 may stop certain proteins that cancer cells need to survive. In this study, researchers will evaluate PU-H71 for the first time in patients by determining the optimal dose of the drug and observing any side effects in patients with skin cancer, solid tumors, or lymphoma that has returned or progressed despite prior therapy.
On the first day of the study, patients will receive PU-H71 labeled with a small amount of radioactive iodine. This will enable doctors to perform a positron emission tomography (PET) scan to see how the drug is taken up in cancer cells. Patients may also choose to give a tumor tissue sample via needle biopsy so researchers can examine levels of PU-H71 in the tissue.