A Phase II Study of Neoadjuvant Pemetrexed Plus Cisplatin for Patients with Resectable Non-Squamous Non-Small Cell Lung Cancer with "Switch Chemotherapy Alternative" in Non-Responders (NEOSCAN)

Patients with non-small cell lung cancer often require chemotherapy prior to surgery to improve their chance of a cure. Pemetrexed and cisplatin are the best drugs for the treatment of non-squamous non-small cell lung cancer.

This study will use novel ways to monitor shrinkage of the tumor during chemotherapy. Patients will have PET scans before and after chemotherapy.

For patients whose tumor does not shrink, this study will give them a different chemotherapy: vinorelbine and docetaxel. The goal of his study is to measure the safety and effectiveness of switching to a different chemotherapy regimen in patients whose tumor does not shrink using the first chemotherapy.