Paclitaxel and carboplatin are two standard drugs commonly used to treat solid tumors. ABT-888 is an investigational drug that may prevent cancer cells from repairing the damage inflicted by chemotherapy drugs. The combination of ABT-888 with conventional anticancer drugs may make the chemotherapy work better.
People with liver or kidney problems may metabolize drugs differently than people with normal liver and kidney function. In this study, researchers want to find the best dose of ABT-888 that can be used in people with advanced solid tumors who have liver or kidney problems.