Clinical Trials

Use of High-Resolution Structural MRI to Assess Changes in Brain Structure Related to Chemotherapy in Patients with Non-Small Cell Lung Cancer: A Prospective Study

Protocol
11-145
Full Title
Changes in Brain Structure Related to Systemic Chemotherapy Treatment: A Prospective Study in Individuals Diagnosed with Non-small Cell Lung Cancer Utilizing High-resolution Structural Magnetic Resonance Imaging
Purpose

Some cancer patients report changes in their memory or thinking after treatment (referred to by some patients as “chemo brain”). These changes could be a result of alterations in brain structure, such as changes in the size or thickness of different parts of the brain. The purpose of this study is to evaluate the effects of cancer treatment on the brain.

Researchers will compare high-resolution structural magnetic resonance imaging (MRI) scans between non-small cell lung cancer (NSCLC) patients who had surgery and chemotherapy and NSCLC patients who had surgery alone. Patients will have an MRI before surgery and about seven months after surgery.

Investigator
James C. Root - Physician Profile
Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have a confirmed diagnosis of NSCLC and be scheduled for surgery, with or without chemotherapy containing cisplatin or carboplatin.
  • Patients’ NSCLC may not have spread to the brain.
  • Patients must be able to undergo MRI (i.e., not have any metal implants or pacemakers).
  • Patients should be able to understand English.
  • Patients must be ages 50 to75.

For more information about this study, please contact Dr. James Root at 646-888-0035.

Disease(s)
Lung Cancer
Lung Cancer, Non-Small Cell
Lung Cancer, Non-Small Cell: Lung Adenocarcinoma
Survivorship
Locations
ClinicalTrials.gov
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