Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future.
There are some features of kidney tumors in children that may predict tumor behavior and how patients respond to treatment. The purpose of this Children’s Oncology Group study is to collect, store, and study kidney tumor tissues and blood samples from children with kidney tumors to learn more about the biology of these cancers. This information may be used to tailor the most appropriate therapy for each patient to increase the chance of a good outcome, and for further study to help other patients diagnosed with kidney tumors in the future.
In addition, parents of children with malignant rhabdoid tumors who are enrolled in this study may be asked if they would like to donate a blood sample for genetic analysis. Researchers will see how many children with these cancers have mutations in a gene called INI1, which is related to the development of rhabdoid tumors and may be associated with their behavior. Parents of children found to have INI1 mutations may have their blood tested to see if they, too, have the mutation and had passed it on to the child.