Studies have shown that giving the cisplatin-based chemotherapy before bladder removal surgery in patients with bladder cancer that has invaded the nearby muscle helps patients live longer than if they had surgery alone. The combination of cisplatin and gemcitabine is commonly used in this setting. The purpose of this study is to evaluate the safety and effectiveness of giving gemcitabine and cisplatin in a “dose-dense” schedule before bladder removal surgery in patients with muscle-invasive bladder cancer.
Dose-dense chemotherapy means the anticancer drugs are given more frequently than the standard treatment regimen. Some studies suggest that patients with cancer who receive dose-dense chemotherapy that includes cisplatin live longer than those who receive chemotherapy according to the standard dosing schedule.