A Prospective Phase II Study of Brachytherapy in Men with Prostate Cancer that Returned after Prior External Beam Radiation Therapy

Protocol
12-098
Full Title
A Prospective Phase II Trial of Transperineal Ultrasound-Guided Brachytherapy For Locally Recurrent Prostate Adenocarcinoma Following External Beam Radiotherapy (RTOG 0526)
Purpose

External beam radiation therapy and brachytherapy are options for the initial treatment of localized prostate cancer. Brachytherapy involves the implantation of tiny radioactive seeds near the tumor.

In this Radiation Therapy Oncology Group study, researchers are evaluating the effectiveness and side effects of brachytherapy when used in men with prostate cancer that has returned despite previous external beam radiation therapy. The radiation dose to be used in this study is slightly lower than that used in standard initial brachytherapy. Doctors are extra cautious about exposing nearby healthy tissue to radiation, since patients have already received prior radiation therapy to the prostate.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have localized, non-metastatic prostate cancer that has returned more than 30 months since completion of external beam radiation therapy.
  • Patients must have a PSA level of less than 10 ng/ml.
  • Patients must be age 18 or older.

For more information about this study and to inquire about eligibility, please contact Dr. Marisa Kollmeier at 212-639-3952.

Disease(s)
Prostate Cancer
Prostate Cancer: Localized Disease
Prostate Cancer: Rising PSA After Primary Therapy
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