Clinical Trials

A Phase I Study of MED14736 in Patients with Advanced Solid Tumors

Protocol
12-179
Full Title
A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI4736 in Subjects With Advanced Solid Tumors
Purpose

The purpose of this study is to find the highest dose of the investigational drug MED14736 which can be given safely in patients with advanced melanoma, renal cell cancer, colorectal cancer, or non-small cell lung cancer that is no longer responding to treatment. MED14736 is an antibody designed to boost the body’s immune system by targeting a protein on tumor cells called PDL-1.

PDL-1 normally maintains the balance of the immune system. In cancer, PDL-1 helps tumors evade detection and elimination by the immune system. MED14736 may increase the immune system’s ability to identify and destroy cancer cells. It is given intravenously (by vein).

Investigator
Neil H. Segal, MD, PhD
Neil H. Segal - Physician Profile
Co-Investigators
Pictured: Jedd Wolchok
Jedd D. Wolchok - Physician Profile
Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must have advanced melanoma, renal cell carcinoma, colorectal cancer, or non-small cell lung cancer that is no longer responding to treatment.
  • Any serious side effects of prior therapies must have resolved before the patient enters the study.
  • Patients must be physically well enough that they are fully ambulatory, capable of all self care, and are capable of all but physically strenuous activities. As an example, patients must be well enough that they would be able to carry out office work or light housework.
  • This study is open to patients age 18 and older.

For more information about this study and to inquire about eligibility, please contact the office of Dr. Neil H. Segal at 646-888-4187.

Locations
ClinicalTrials.gov