Amyloidosis is a disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid deposits. Amyloidosis may be treated with chemotherapy, but the disease often returns.
In this study, researchers want to find the highest dose of the drug carfilzomib that can be given safely in patients with systemic light chain amyloidosis that persists or has returned despite prior therapy. Carfilzomib is a proteasome inhibitor. The proteasome breaks down proteins that are no longer useful to a cell. Proteasome inhibitors turn off the proteasome, causing the proteins to build up in the cell, resulting in cell death. Turning off the proteasome may inhibit the progression of systemic light chain amyloidosis.
Carfilzomib is already approved for treating some patients with multiple myeloma; its use in this study is considered investigational. It is given intravenously (by vein).