Breast-conserving surgery with lumpectomy (removal of a breast tumor, but not the whole breast) followed by radiation therapy has been shown to be as effective as mastectomy (removal of the entire breast) for women with a single tumor in one breast. Mastectomy has been the traditional surgery for women with more than one tumor in the same breast.
In this study, researchers want to determine if lumpectomy plus radiation therapy is as effective as mastectomy for reducing the risk of cancer recurrence in women with two or three tumors in the same breast, and to assess how satisfied patients and their surgeons are with the cosmetic appearance of the breast. All women in this study will have breast-conserving surgery followed by radiation therapy to the entire affected breast. Investigators will observe how many patients in this study eventually need to return for a mastectomy, and also examine the side effects of whole breast radiation given after lumpectomy.
This study is being conducted by the American College of Surgeons Oncology Group (ACOSOG) through Alliance for Clinical Trials in Oncology (Alliance).