With an autologous stem cell transplant (ASCT), some of a patient’s stem cells are removed before chemotherapy and then returned to the patient to help re-establish the patient’s immune system. However, patients who undergo this procedure have a weakened immune system, and may be more susceptible to infections such as shingles (which is caused by the herpes zoster virus). Shingles causes a rash and can produce very uncomfortable nerve pain.
The purpose of this study is to see if giving a new type of shingles vaccine to patients who have had an ASCT is effective for preventing shingles infection. The vaccine being evaluated in this study is designed to stimulate immunity against the herpes zoster virus. Patients in this study will be randomly assigned to receive two injections of the shingles vaccine or a placebo (injections of saline, a mild salt water solution).