Bortezomib, dexamethasone, and lenalidomide are often given together to treat newly diagnosed multiple myeloma (a cancer of the bone marrow). However, this combination of three drugs is associated with significant side effects. Doctors may be able to achieve the same results using only two drugs and add the third drug only in patients who do not respond to the two-drug combination.
In this study, researchers will first give patients just two of the drugs (bortezomib and dexamethasone). Patients will only receive lenalidomide if their myeloma is not well controlled with bortezomib and dexamethasone alone. Doctors hope that giving the myeloma drugs in this way will be as effective as using all three drugs at the same time from the beginning, but with less side effects.