Temozolomide is a standard treatment for an aggressive type of brain cancer called glioblastoma. However, this type of cancer is challenging to treat and usually continues to grow despite surgery, chemotherapy, and radiation therapy.
In this study, researchers want to find the optimal dose of an investigational drug called MK-1775 which can be given in combination with temozolomide and radiation therapy in patients newly diagnosed with glioblastoma. MK-1775 works by inhibiting an enzyme called Wee, which is very active in glioblastoma and can make the tumor resistant to radiation therapy. It is also hoped that MK-1775 will make the cancer cells more vulnerable to temozolomide.
Patients will be placed in one of two groups. In one group (Arm 1), researchers will determine the highest dose of MK-1775 that can be given safely with temozolomide taken daily during the six-week course of radiation therapy. In the second group (Arm 2), researchers will determine the highest dose of MK-1775 that can be given safely with temozolomide for five days out of every four weeks following the completion of radiation therapy.