The purpose of this study is to find the highest dose of the investigational drug DS-3032B that can be given safely in patients with advanced solid tumors and lymphomas that are not responding well to standard treatments or for which no standard treatment exists. DS-3032B works against cancer by blocking the activity of a protein called MDM2.
Normal MDM2 helps cells to grow and then die, but when MDM2 is damaged, cancer cells can grow continuously. DS-3032B targets cancer cells with damaged MDM2. It can only work when a patient’s tumor also has normal, functioning p53 (a protein which puts the brakes on rampant cell growth), so patients’ tumors must contain normal p53 for DS-3032B to work.
DS-3032B is taken orally (by mouth).