A Phase II Study of the MatriStem Surgical Matrix to Reinforce the Esophagus in Patients Having Surgery for Gastric and Esophageal Cancer

Protocol
13-178
Full Title
A Prospective Phase II Trial to Evaluate Esophageal Reinforcement with ACell MatriStem Surgical Matrix: A Degradable Biologic Scaffold Material
Phase
II
Disease Status
Newly Diagnosed & Relapsed/Refractory
Purpose

In patients who have had a tumor surgically removed from the esophagus or stomach, a complication may occur at the site where the two ends of the gastrointestinal tract were reconnected (“anastomosis”), causing leakage or a narrowing (“stricture”). About 10 percent of patients experience these complications, extending their hospital stay and often requiring them to have more tests and procedures.

In this study, surgeons are determining if a product called MatriStem can help reduce the risk of these complications when wrapped, like a blanket, around the site of the connection.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

  • Patients must be planning to undergo surgery to remove a tumor of the esophagus, stomach, or junction between the esophagus and stomach that requires a reconnection of two ends of the esophagus.
  • Patients with metastatic cancer may not participate.
  • This study is open to patients age 18 and older.

For more information about this study and to inquire about eligibility, please contact Dr. Vivian Strong at 212-639-5056.

Disease(s)
Upper Gastrointestinal: Esophageal Cancer
Upper Gastrointestinal: Gastric Cancer
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