Women who have a mastectomy as treatment for locally advanced breast cancer may need radiation therapy afterward. But in women who received a breast implant (a tissue expander or permanent implant) as part of breast reconstruction, the radiation may damage the implant. In this study, researchers are evaluating the effectiveness of a different form of radiation therapy for these patients to see if it results in fewer complications.
With the standard method, three-dimensional radiation is delivered using two to five radiation beams. With the investigational method being assessed in this study, eight to twelve small radiation beams will be delivered through an approach called multi-beam intensity-modulated radiation therapy (IMRT). This method enables highly tailored radiation to be given to the implant, breast, chest wall, and lymph nodes. Multi-beam IMRT may also lower the radiation dose to the heart, lungs, and other nearby healthy tissues.