Paclitaxel and carboplatin are chemotherapy drugs commonly used to treat ovarian cancer. However, the cancer often returns. This may be because these cancer drugs do not target cancer stem cells. Cancer stem cells are thought to be involved in cancer spread and recurrence and are often resistant to traditional anticancer therapy.
OMP-54F28 is an investigational drug designed to block the growth of cancer stem cells. It may work particularly well when given with paclitaxel and carboplatin. In this study, researchers want to find the highest dose of OMP-54F28 that can be given safely with paclitaxel and carboplatin in women with ovarian, fallopian tube, or primary peritoneal cancer that initially responded to platinum-based therapy but then came back.
All three drugs are given intravenously (by vein).