Paclitaxel and carboplatin are standard chemotherapy drugs used to treat endometrial cancer. One way to make treatment more effective is to add new drugs to standard therapy. In this Gynecologic Oncology Group study, researchers want to see if adding the drug metformin to paclitaxel and carboplatin is more effective against advanced and recurrent endometrial cancer than paclitaxel/carboplatin alone.
Metformin is a drug commonly used to treat diabetes, but its use in this study is considered investigational. Other studies have suggested that metformin may be useful for preventing or treating certain cancers. It is a pill that is taken orally (by mouth). Paclitaxel and carboplatin are given intravenously (by vein).
Women in this study will be randomly assigned to receive either paclitaxel, carboplatin, and metformin OR paclitaxel, carboplatin, and placebo.