Advanced MR Imaging in Brain Tumors

Department
Radiology
Description

Advanced MR imaging includes techniques such as T1 and T2 perfusion, diffusion tensor, and spectroscopy that investigate biological processes of the tumor to provide insight into tumor behavior and prognosis. Imaging biomarkers are important surrogate end points in clinical trials for patients with brain tumors, with tumor progression commonly defined as increased or newly enhanced mass lesions. Enhancement has become a less reliable indicator for tumor progression, however, with the emergence of targeted treatments, including antiangiogenic and immune-based treatments that directly affect tumor microvasculature and thus modify enhancement. This study looks to build upon prior work, correlating imaging with genetic mutation status, predicting prognosis, predicting outcome, and determining treatment response vs. failure.

Project Type

Translational Research

Preferred Project Dates

  • June 15 – August 7
  • June 22 – August 14
Student's Role

The student will have the opportunity to select a specific project before the summer. With appropriate training and supervision, the student will be directly responsible for analyzing advanced MR imaging data on a dedicated workstation. By the end of the project, the student should be prepared to submit their work as an abstract to a national meeting and write a manuscript for publication as the first or co-first author. Previous students have presented 12 abstracts, published six papers (three as first author), and one received an Outstanding Oral Presentation Award at the 2014 American Society of Neuroradiology meeting.

There will be opportunities to observe interventional neuroradiology procedures, functional MRI scanning, intraoperative MRI scanning, and awake brain tumor surgeries. The student is expected to actively participate in the Neuroradiology Service, and attend daily Department of Neurology working rounds, weekly Functional MRI Laboratory and multidisciplinary disease management team conferences. Existing computer skills are helpful but are not required. Applicants to the project are asked to briefly describe any relevant past experiences, current interests, and future plans in their statement.

Extent of Research/Laboratory, Clinical, and Didactic Activities
  • Clinical Research: 80%
  • Clinical Activities (Time attending clinics, shadowing, and/or OR observation): 10%
  • Didactics (Lab, DMT meetings, and/or other weekly conferences): 10%

Summer Fellowship Online Application