Center News Magazine: PhD Recipients, Their Thesis Titles, and Mentors

Wednesday, July 1, 2009

Carrie Ann Adelman
Analysis of Mre11 Complex Roles in Response to Physiological Sources of DNA Damage in the Mouse
Faculty Mentor: John Petrini, PhD

Claudio Alarcon
Role of the Linker Region of Smad Proteins in the Regulation of the TGF-beta and BMP Signaling Pathways
Faculty Mentor: Joan Massagué, PhD

Jideofor Aniukwu*
The Pathways and Outcomes of Mycobacterial NHEJ Depend on the Structure of the Broken DNA Ends
Faculty Mentor: Stewart Shuman, MD, PhD, and Michael Glickman, MD

Eli Berdougo
Human Cdc14 Phosphatases Are Not Essential for Viability and Do Not Regulate Mitotic Exit
Faculty Mentor: Prasad Jallepalli, MD, PhD

Zhenjian Cai
Structural Studies of the Regulation of the DNA Damage Checkpoint Kinase Chk2
Faculty Mentor: Nikola Pavletich, PhD

Zhucheng Chen
Mechanism of Homologous Recombination from Structures of RecA/Single-Stranded DNA and RecA/Double-Stranded DNA Filaments
Faculty Mentor: Nikola Pavletich, PhD

Server Adil Ertem
Catena: A Novel Cellular Entity Composed of Ovarian Cancer Stem Cells
Faculty Mentor: Malcolm Moore, DPhil

Zhonghua Gao
Regulation of the Molecular Machinery of Programmed Cell Death
Faculty Mentor: Xuejun Jiang, PhD

Jaclyn Caye Greimann
Structure and Biochemistry of the Eukaryotic RNA Exosome
Faculty Mentor: Christopher Lima, PhD

Ensar Halilovic
The Role of Mutational Activation of RAS and PI3K Signaling Pathways in Human Tumors: Biologic and Therapeutic Implications
Faculty Mentor: Neal Rosen, MD, PhD

Ting Jia
Analysis of CC-Chemokines and Monocyte Trafficking in Innate Immune Defense Against Listeria Monocytogenes
Faculty Mentor: Eric Pamer, MD

Lucy Willis Kappel
The Role of Th17-Related Cytokines in Murine Graft-Versus-Host Disease
Faculty Mentor: Marcel van den Brink, MD, PhD

Nirsoshika Ashanthi Keppetipola
Biological and Biochemical Specificities of Binuclear Metallophosphoesterases
Faculty Mentor: Stewart Shuman, MD, PhD

John Charles Markley*
Tumor-Specific Human Primary T Cells Engineered to Overexpress IL-2, IL-7, IL-15, or IL-21 Confer Varying Degrees of Tumor Rejection and Xenogeneic Graft-Versus-Host Disease in an Immunodeficient Mouse Model
Faculty Mentor: Michel Sadelain, MD, PhD

Mohamed Firaz Mohideen
Biochemical and Structural Insights into SUMO Conjugation and Recognition
Faculty Mentor: Christopher Lima, PhD

Hyung-Song Nam*
The Molecular Identity of Neural Stem Cells: High Levels of Id1 Expression Defines B1 Type Adult Neural Stem Cells
Faculty Mentor: Robert Benezra, PhD

David Miguel Padua*
Identifying a Role for TGF-beta Signaling in Breast Cancer Metastasis to the Lungs
Faculty Mentor: Joan Massagué, PhD

Lisa M. Placanica
Endogenous Gamma Secretase: Activity, Substrate Selectivity, and Subunit Composition
Faculty Mentor: Yueming Li, PhD

Alejandro Ramirez
Analysis of RNA Phosphotransferase and tRNA Splicing Activities of Human Clp1
Faculty Mentor: Stewart Shuman, MD, PhD

Catherine Leah Randall
Genetic Dissection of Polo-like Kinase 1’s Functions in Human Cell Division
Faculty Mentor: Prasad Jallepalli, MD, PhD

Brian Edward Richardson
Actin Cytoskeleton Remodeling Is Essential for Myoblast Fusion in Drosophila
Faculty Mentor: Mary Baylies, PhD

Gabrielle Ann Rizzuto*
Self-Antigen Specific CD8+ T Cell Precursor Frequency Determines the Quality of the Anti-tumor Immune Response
Faculty Mentor: Alan Houghton, MD

Elizabeth Romero
Role of Id1 in Embryonic Stem Cell Self-Renewal and Differentiation
Faculty Mentor: Robert Benezra, PhD

Shiying Shang
A Unified Synthetic Approach to Polyketides Having Both Skeletal and Stereochemical Diversity
Faculty Mentor: Derek Tan, PhD

Christopher Chad Shelton
Gamma Secretase Regulation and Function in Alzheimer Disease and Non-Hodgkin’s Lymphoma
Faculty Mentor: Yueming Li, PhD

Barry Stephen Taylor
Integrative Characterization of Chromosomal Aberrations in Human Cancer
Faculty Mentor: Chris Sander, PhD

Olisambu Uche
The BTB-Zinc Finger Transcriptional Regulator, PLZF, Controls the
Development of iNKT Cell Innate Effector Functions

Faculty Mentor: Derek Sant’Angelo, PhD

Ming-Ching Wong
Regulation of Twist Activity During Mesoderm and Somatic Muscle Development in Drosophila
Faculty Mentor: Mary Baylies, PhD

Guozhou Xu
Crystal Structures of the Fanconi Anemia Proteins
Faculty Mentor: Nikola Pavletich, PhD

Kai Xu
Host Cell Recognition by Henipa-Virus: Crystal Structures of Henipa-Virus Attachment Glycoproteins and the Complexes with Receptors
Faculty Mentor: Dimitar Nikolov, PhD

Ali Asgar Yunus
Structural and Biochemical Studies of the Sumo Conjugation Pathway
Faculty Mentor: Christopher Lima, PhD

*MD/PhD