Major Research Areas

Publications

Gaczynska M, Osmulski PA, Jiang Y, Lee JK, Bermudez V and Hurwitz J. Atomic force microscopic analysis of the binding of the Schizosaccharomyces pombe origin recognition complex and the spOrc4 protein with origin DNA. Proc Natl Acad Sci USA 2004; 101:17952-7.

Giordano-Coltart J, Ying CY, Gautier J and Hurwitz J. Studies of the properties of human origin recognition complex and its Walker A motif mutants. Proc Natl Acad Sci USA 2005; 102:69-74.

Fien K, Cho Y-S, Lee J-K, Raychaudhuri S, Tappin I, and Hurwitz J. Primer Utilization by DNA Polymerase a-Primase is Influenced by Its Interaction withMcm10p. J Biol Chem 2004; 279:16144-16153.

BermudezVP, Maniwa Y, Tappin I, Ozato K, Yokomori K and Hurwitz J. The alternative Ctf18-Dcc1-Ctf8-RFC complex required for sister chromatid cohesion loads PCNA onto DNA. Proc Natl Acad Sci USA 2003; 18:10237-10242.

Shin JH, Jiang Y, Grabowski B, Hurwitz J, Kelman Z. Substrate requirements for duplex DNA translocation by the eukaryal and archaeal minichromosome maintenance helicases. J Biol Chem. 2003; 278:49053-62.

Kelman Z, Hurwitz J. Structural lessons in DNA replication from the third domain of life. Nat Struct Biol. 2003; 10:148-50.

Lee JK, Seo YS, Hurwitz J. The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome
maintenance complex by the Dfp1-Hsk1 kinase. Proc Natl Acad Sci U S A. 2003; 100:2334-9.

Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J, Sancar A. Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci U S A. 2003; 100:1633-8.

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