Major Research Areas

Publications

Keeney S, Kleckner N. Covalent protein-DNA complexes at the 5' strand termini of meiosis-specific double-strand breaks in yeast. Proc Natl Acad Sci USA. 1995;92:11274-11278.

Keeney S, Kleckner N. Communication between homologous chromosomes: genetic alterations at a nuclease-hypersensitive site can alter mitotic chromatin structure at that site both in cis and in trans. Genes Cells. 1996;1:475-489.

Keeney S, Giroux CN, Kleckner N. Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family. Cell. 1997;88:375-384.

Keeney S, Baudat F, Angeles M, Zhou ZH, Copeland NG, Jenkins NA, Manova K, Jasin M. A mouse homolog of the S. cerevisiae meiotic recombination DNA transesterase Spo11p. Genomics. 1999;61:170-182.

Baudat F, Manova K, Yuen JP, Jasin M, Keeney S. 2000 Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Mol Cell. 2000;6;989-998.

Baudat F, Keeney S. 2001 Meiotic recombination: Making and breaking go hand in hand. Curr Biol. 2001;11:R45-R48.

Keeney S. 2001 Mechanism and control of meiotic recombination initiation. Curr Top Dev Biol. 2001;52;1-53.

Kee K, Keeney S. 2002 Functional interactions between SPO11 and REC102 during initiation of meiotic recombination in Saccharomyces cerevisiae. Genetics. 2002;160;111-122.

Klein U, Esposito G, Baudat F, Keeney S, Jasin M. 2002 Mice deficient for the type II topoisomerase-like DNA transesterase Spo11 show normal immunoglobulin somatic hypermutation and class switching. Eur J Immunol. 2002;32;316-321.

Diaz RL, Alcid AD, Berger JM, Keeney S. 2002 Identification of residues in yeast Spo11p critical for meiotic DNA double-strand break formation. Mol Cell Biol. 2002;22:1106-1115.

Martini EM, Keeney S, Osley MA. 2002 A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae. Genetics. 2002;160:1375-1387.

Martini E, Keeney S. 2002 Sex and the single (double-strand) break. Mol Cell. 2002;9:700-702.

Arora C, Kee K, Maleki S, Keeney S. 2004 Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell. 2004;13:549-559.

Henderson KA, Keeney S. Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks. Proc Natl Acad Sci USA. 2004;101:4519-4524.

Kee K, Protacio RU, Arora C, Keeney S. Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J. 2004;23:1815-1824.

Kauppi L, Jeffreys AJ, and Keeney S (2004) Where the crossovers are: Recombination distributions in mammals.
Nature Rev. Genet. 5, 413-424.

Maleki S, and Keeney S (2004) Modifying histones and initiating meiotic recombination: New answers to an old
question. (Preview) Cell 118, 404-406.

Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, and Jasin M (2005) Distinct DNA damage-dependent and
independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc. Natl. Acad. Sci. USA
102, 737-742.

Okada T, and Keeney S (2005) Homologous recombination: Needing to have my say. (Dispatch) Curr. Biol.15, R200-R202.

Ahn S-H, Henderson KA, Keeney S, and Allis CD (2005) H2B (Ser10) phosphorylation is induced during apoptosis and
meiosis in S. cerevisiae. Cell Cycle 4, 780-783.

Barchi M, Mahadevaiah S, Di Giacomo M, Baudat F, de Rooij DG, Burgoyne PS, Jasin M, and Keeney S (2005). Surveillance of
different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical
developmental stage. Mol. Cell. Biol. 25, 7203-7215.

Neale MJ, Pan J, and Keeney S (2005) Endonucleolytic processing of covalent protein-linked DNA double-strand breaks.
Nature 436, 1053-1057.

Henderson KA and Keeney S (2005) Synaptonemal complex formation: Where does it start? Bioessays 27, 995-998.

Henderson K, Kee K, Maleki S, Santini PA, and Keeney S (2006) Cyclin-dependent kinase directly regulates initiation of
meiotic recombination. Cell 125, 1321-1332.

Neale MJ and Keeney S (2006) Clarifying the mechanics of DNA strand exchange in meiotic recombination. (Invited review).
Nature 442: 153-158.

Martini E, Diaz RL, Hunter N, and Keeney S (2006). Crossover homeostasis in yeast meiosis. Cell 126: 285-295.

Keeney S and Neale MJ (2006) Initiation of meiotic recombination by formation of DNA double-strand breaks:
mechanism and regulation. (Meeting proceedings). Biochem. Soc. Trans., 34, 523-525.

Liebe B, Pethukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, Pandita MTK, Jasin M, Fornace A, Meistrich ML, Baarends WM, Schimenti J, de Lange T, Keeney S, Camerini-Otero RD, and Scherthan H (2006). Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp. Cell Res. 312, 3768-3781.

Keeney S (2007) Spo11 and the formation of DNA double-strand breaks in meiosis. In Genome Dynamics and Stability, vol. 2, "Recombination and Meiosis: Crossing Over and Disjunction." R. Egel and D.-H. Lankenau, Eds., Springer, Berlin, pp. 81-123.

Maleki S, Neale MJ, Arora C, Henderson KA, and Keeney S (2007) Interactions between Mei4, Rec114, and other proteins required for meiotic DNA double-strand break formation in Saccharomyces cerevisiae. Chromosoma 116, 471-486.

Kauppi L, Jasin M, and Keeney S (2007) Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome. Proc. Natl. Acad. Sci. USA 104, 13396-13401.

Pan J and Keeney S (2007) Molecular cartography: Mapping the landscape of meiotic recombination. (Invited primer.) PLoS Biology 5, 2775-2777.

Murakami H and Keeney S (2008) Regulating the formation of DNA double-strand breaks in meiosis. (Perspective article.) Genes Dev. 22, 286-292.

Barchi M, Roig I, Cole F, Di Giacomo M, de Rooij DG, Keeney S, and Jasin M (2008) ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet. 4, e1000076.

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