Research Programs Cancer Biology & Genetics Cell Biology Computational Biology Developmental Biology Immunology Molecular Biology David Allis @ Rockefeller.edu Robert Fisher Jerard Hurwitz Prasad Jallepalli Scott Keeney Thomas J. Kelly Andrew Koff Kenneth J. Marians John Petrini Simon N. Powell Mark Ptashne Stewart Shuman Paul Tempst Xiaolan Zhao Molecular Pharmacology & Chemistry Structural Biology Postdoctoral Training Graduate Education Summer Undergraduate Research Program Core Facilities Collaborative Research Centers Sloan-Kettering Institute > Research Programs > Molecular Biology > Scott Keeney > Projects > Meiotic Recombination in the Mouse Selected Publications Keeney S, Baudat F, Angeles M, Zhou Z-H, Copeland NG, Jenkins NA, Manova K, Jasin M. 1999 A mouse homolog of the Saccharomyces cerevisiae meiotic recombination DNA transesterase Spo11p. Genomics. 1999;61:170-182. Baudat F, Manova K, Yuen JP, Jasin M, Keeney S. 2000 Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Mol Cell. 2000;6:989-998. Mahadevaiah SK, Turner JMA, Baudat F, Rogakou EP, de Boer P, Blanco-Rodriguez J, Jasin M, Keeney S, Bonner WM, Burgoyne PS. 2001 Recombinational DNA double strand breaks in mice precede synapsis. Nat Genet. 2001;27:271-276. Kauppi L, Jeffreys AJ, and Keeney S (2004) Where the crossovers are: Recombination distributions in mammals. Nature Rev. Genet. 5, 413-424. Di Giacomo M, Barchi M, Baudat F, Edelmann W, Keeney S, and Jasin M (2005) Distinct DNA damage-dependent and independent responses drive the loss of oocytes in recombination-defective mouse mutants. Proc. Natl. Acad. Sci. USA 102, 737-742. Barchi M, Mahadevaiah S, Di Giacomo M, Baudat F, de Rooij DG, Burgoyne PS, Jasin M, and Keeney S (2005). Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. Mol. Cell. Biol. 25, 7203-7215. Neale MJ, Pan J, and Keeney S (2005) Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature 436, 1053-1057. Kauppi L, Jasin M, and Keeney S (2007) Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome. Proc. Natl. Acad. Sci. USA 104, 13396-13401. Barchi M, Roig I, Cole F, Di Giacomo M, de Rooij DG, Keeney S, and Jasin M (2008) ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet. 4, e1000076. Return to Meiotic Recombination in the Mouse Main Page

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