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- Interactions of p27 with Other Proteins
There are 2 questions being addressed in the laboratory on this issue. First, cell cycle exit is accompanied by a reduction in G1 cyclin-cdk activity due to a rapid accumulation of a member or members of the stoichiometric cdk-inhibitor families, the Ink4 family, or the Cip/Kip family. - Why is p27 Loss Prognostic for Tumor Development?
We and others have demonstrated that the loss of p27 expression in human tumors of the colon, prostate, breast, etc. correlates with poor prognosis. However, there is no understanding of why this is so. - Regulation of p27
There are 2 projects underway in the laboratory. One to understand how proteolysis controls the abundance of p27, and the other to understand how translational regulatory signals control p27 abundance.
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