Major Research Areas

Publications

Mechanisms of Replication Fork Reactivation

Marians KJ. Understanding how the replisome works. Nat Struct Mol Biol. 2008; 15:125-7.

Heller RC, Marians KJ. Non-replicative helicases at the replication fork. DNA Repair (Amst). 2007; 6:945-52.

Heller RC, Marians KJ. Replisome assembly and the direct restart of stalled replication forks. Nat Rev Mol Cell Biol. 2006;
7:932-43.

Heller RC, Marians KJ. Replication fork reactivation downstream of a blocked nascent leading strand. Nature. 2006; 439:
557-62.

Heller RC, Marians KJ. Unwinding of the nascent lagging strand by Rep and Pria enables the direct restart of stalled
replication forks. J Biol Chem. 2005; 280:34143-51.

Heller RC, Marians KJ. The disposition of nascent strands at stalled replication forks dictates the pathway of replisome
loading during restart. Mol Cell. 2005; 17:733-43.

Marians KJ. Mechanisms of Replication Fork Restart in Escherichia coli. Philos Trans R Soc Lond B Biol Sci. 2004;359:71-77.

Xu L, Marians KJ. PriA mediates DNA replication pathway choice at recombination intermediates. Mol Cell. 2003;11:817-826.

Xu L, Marians KJ. A dynamic RecA filament permits DNA polymerase-catalyzed extension of the invading strand in recombination intermediates. J Biol Chem. 2002;277:14321-14328.

McGlynn P, Lloyd RG, Marians KJ. Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled. Proc Natl Acad Sci USA. 2001;98:8235-8240.

Xu L, Marians KJ. Purification and characterization of DnaC810, a primosomal protein capable of bypassing PriA function. J Biol Chem. 2000;275:8196-8205.

Marians KJ. PriA-directed replication fork restart in Escherichia coli. Trends Biochem Sci. 2000;25;185-189.

Cox MM, Goodman MF, Kreuzer KN, Sherratt DJ, Sandler SJ, Marians KJ. The importance of repairing stalled replication forks. Nature. 2000;404:37-41.

Sandler SJ, Marians KJ. Role of PriA in replication fork reactivation in Escherichia coli. J Bacteriol. 2000;182:9-13.

Liu J, Xu L, Sandler SJ, Marians KJ. Replication fork assembly at recombination intermediates is required for bacterial growth. Proc Natl Acad Sci USA. 1999;96:3552-3555.

Nurse P, Liu J, Marians KJ. Two modes of PriA binding to DNA. J Biol Chem. 1999;274:25026-25032.

Nurse P, Liu J, Marians KJ. Two modes of PriA binding to DNA. J Biol Chem. 1999;274:25026-25032.

Nurse P, Zavitz KH, Marians KJ. Inactivation of the Escherichia coli priA DNA replication protein induces the SOS response. J Bacteriol. 1991;173:6686-6693.

Chromosome Dynamics and Cytokinesis

Suski C, Marians KJ. Resolution of converging replication forks by RecQ and topoisomerase III. Mol Cell. 2008; 20:779-89.

Espeli O, Marians KJ. Untangling intracellular DNA topology. Mol Microbiol. 2004;52:925-931.

Espeli O, Levine C, Hassing H, Marians KJ. Temporal regulation of topoisomerase IV activity in E. coli. Mol Cell. 2003;11:189-201.

Espeli O, Nurse P, Levine C, Lee C, Marians KJ. SetB: an integral membrane protein that affects chromosome segregation in Escherichia coli. Mol Microbiol. 2003;50:495-509.

Espeli O, Lee C, Marians KJ. A physical and functional interaction between Escherichia coli FtsK and topoisomerase IV. J Biol Chem. 2003;278:44639-44644.

Nurse P, Levine C, Hassing H, Marians KJ. Topoisomerase III can serve as the cellular decatenase in Escherichia coli. J Biol Chem. 2003;27:8653-8660.

Levine C, Marians KJ. Identification of dnaX as a high-copy suppressor of the conditional lethal and partition phenotypes of the parE10 allele. J Bacteriol. 1998;180:1232-1240.

Peter BJ, Ullsperger C, Hiasa H, Marians KJ, Cozzarelli NR. The structure of supercoiled intermediates in DNA replication. Cell. 1998;9:819-827.

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